Testosterone replacement therapy (TRT): What you need to know

What is Testosterone?

Testosterone is a hormone primarily produced in the testicles in men and in smaller amounts in women’s ovaries. It plays a key role in:

• Sexual function: Libido, erections, and sperm production

• Physical Health: Muscle mass, bone density, and fat distribution.

• Mood and energy: Vitality, mood stability, and cognitive function.

What is Testosterone Deficiency?

As men age, testosterone levels naturally decline. However, some men experience significant decreases in testosterone, leading to symptoms like:

• Low libido and erectile dysfunction 

• Fatigue and reduced energy

• Depression or mood swings

• Loss of muscle mass and increased body fat

This condition, often called Low T or hypogonadism, can be diagnosed with a blood test.

What is Testosterone Replacement Therapy (TRT)?

TRT is a medical treatment designed to restore healthy testosterone levels. It can be administered through various methods, including:

• Injections: Regular intramuscular injections.

• Gels or Creams: Topical applications absorbed through the skin

• Patches: Skin patches worn daily

• Pellets: Small pellets implanted under the skin that release testosterone over time.

Scientific Evidence Supporting TRT

1. Improved Sexual Health: 

Men with low testosterone experienced significant improvements in libido, sexual activity, and erectile function after TRT.

1. Enhanced Physical Performance: 

TRT has been shown to increase muscle mass, strength, and reduce fat mass in men with testosterone deficiency.

1. Better Mood and Cognitive Function: 

TRT may help alleviate symptoms of depression and improve cognitive function in men with low testosterone 

1. Bone Density Improvement: 

TRT has been linked to increased bone mineral density, reducing the risk of fractures.

Is TRT Right for you?

TRT can be life-changing for men with low testosterone, but it isn’t suitable for everyone. A consultation with a healthcare provider is necessary if you experience symptoms of low testosterone. A healthcare provider can evaluate your symptoms, conduct blood tests and discuss potential benefits and risks of TRT.

Potential Risks of TRT

While TRT offers many benefits, it is important to be aware of potential side effects, including:

• Increased red blood cell count: This can increase the risk of blood clots.

• Prostate health: Potential to stimulate the growth of existing prostate cancer

• Sleep Apnea: TRT may exacerbate this condition.

• Skin reactions: Topical treatments may cause irritation 

Conclusion

Testosterone Replacement Therapy can restore your vitality, improve your mood, and enhance your quality of life if you are suffering from testosterone deficiency. For more information, schedule a convenient and fast telemedicine visit with one of our providers to discuss the risks, benefits, and whether TRT is appropriate for you. 

This informational blog is based on current medical research and is not a substitute for professional medical advice.

References:

1. Shabsigh, R., et al. (2006). “The effects of testosterone replacement therapy on erectile dysfunction and responses to sildenafil citrate: A multicenter, randomized, double-blind, placebo-controlled trial.” Journal of Sexual Medicine, 3(5), 716-728. Doi:10.1111/j.1743-6109.2006.00287.x

2. Bhasin, S., et al. (2010). “Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline.” The Journal of Clinical Endocrinology & Metabolism, 95(6), 2536-2559. doi:10.1210/jc.2009-2354

3. Zarrouf, F. A., et al. (2009). “The association between testosterone and depression: A systematic review.” Journal of Psychiatric Practice, 15(4), 289-305. doi:10.1097/01.pra.0000358315.88931.fc

4. Snyder, P. J., et al. (1999). “Effects of testosterone replacement on bone density in hypogonadal men.” The Journal of Clinical Endocrinology & Metabolism, 84(6), 1961-1966. doi:10.1210/jcem.84.6.5750

5. Rhoden, E. L., & Morgentaler, A. (2004). “Risks of testosterone-replacement therapy and recommendations for monitoring.” New England Journal of Medicine, 350(5), 482-492. doi:10.1056/NEJMra022251

6. Basaria, S., et al. (2005). “Prostate safety of testosterone therapy in hypogonadal men.” The Journal of Clinical Endocrinology & Metabolism, 90(2), 649-654. doi:10.1210/jc.2004-0802

7. Wang, C., et al. (2004). “Effects of testosterone replacement on sleep, respiratory drive, and sleep-disordered breathing in men.” Chest, 125(3), 1278-1289. doi:10.1378/chest.125.3.1278

8. McNicholas, T. A. (2003). “Topical testosterone therapy: A clinical review.” The Journal of Urology, 170(6 Pt 1), 1882-1885. doi:10.1097/01.ju.0000092041.34012.c7